Mymensingh Zilla School was established in 1846. Initially established as Hardinge School, it was officially renamed Mymensingh Zilla School on November 3, 1853. The school's first headmaster was Bhagawan Chandra Bose, father of the renowned scientist Jagadish Chandra Bose. The main buildings still in use today were constructed in 1912. The school served as a training camp for freedom fighters during the 1971 Liberation War.
Renowned Alumni
- Abu Sayeed Chowdhury - 2nd President of Bangladesh.
- Jagadish Chandra Bose - Polymath physicist, biologist, and pioneer in radio science.
- Syed Nazrul Islam - Acting President of Bangladesh during the Liberation War.
- Anandamohan Bose - Indian political leader and social reformer.
- Jamilur Reza Choudhury - National Professor of Bangladesh and civil engineer.
- Mahmudullah Riyad - National cricketer.
